학과소식
| 제목 | [축] 학부생 21학번 윤유정 공동참여연구 국제학술지 SCI 논문 게재 | ||||
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| 작성자 | 의공학과 | 등록일 | 2024-02-15 | 조회 | 2045 |
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바이오닉스랩 대학원생 임단유 학생과 학부생 21학번 4학년 윤유정학생이 랩온어칩(Lab-on-a-chip)을 개발하고 이를 활용한 유효 치료제 후보물질을 도출한 내용을 담은 ‘인 실리코, 생체 외, 랩온어칩 기술을 활용한 네페린의 아밀로이드 베타 및 타우 응집에 대한 이중 조절 효과 연구’ 논문이 약리학/약학 분야 상위 8%의 국제학술지인 〈생물의학 및 약물치료(Biomedicine & Pharmacotherapy; Impact factor = 7.5)〉 온라인판에 게재 (지도교수: 박인수)에 공동참여하여 논문게재가 되었습니다.
https://www.sciencedirect.com/science/article/pii/S0753332224001070
AbstractAlzheimer’s disease (AD) is characterized by the presence of two critical pathogenic factors: amyloid-β (Aβ) and tau. Aβ and tau become neurotoxic aggregates via self-assembly, and these aggregates contribute to the pathogenesis of AD. Therefore, there has been growing interest in therapeutic strategies that simultaneously target Aβ and tau aggregates. Although neferine has attracted attention as a suitable candidate agent for alleviating AD pathology, there has been no study investigating whether neferine affects the modulation of Aβ or tau aggregation/dissociation. Herein, we investigated the dual regulatory effects of neferine on Aβ and tau aggregation/dissociation. We predicted the binding characteristics of neferine to Aβ and tau using molecular docking simulations. Next, thioflavin T and atomic force microscope analyses were used to evaluate the effects of neferine on the aggregation or dissociation of Aβ42 and tau K18. We verified the effect of neferine on Aβ fibril degradation using a microfluidic device. In addition, molecular dynamics simulation was used to predict a conformational change in the Aβ42-neferine complex. Moreover, we examined the neuroprotective effect of neferine against neurotoxicity induced by Aβ and tau and their fibrils in HT22 cells. Finally, we foresaw the pharmacokinetic properties of neferine. These results demonstrated that neferine, which has attracted attention as a potential treatment for AD, can directly affect Aβ and tau pathology. 학부생으로 세계적인 국제학술지에 논문 게재에 참여하여 좋은 성과를 내어 축하합니다. 앞으로도 많은 랩에서 대학원생 및 학부연구생이 좋은 연구성과가 도출되도록 다들 계속 노력합시다~
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